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Topagen (Topiramate) 50mg, 60 Ct - Genetics Respiratory Remove the teabag and enjoyTopagen 50 mg Tablets contain Topiramate, a broad spectrum anticonvulsant used for the management of epilepsy and the prevention of migraine headaches. It works through multiple complementary mechanisms: it blocks voltage gated sodium channels to inhibit neuronal firing, potentiates GABA activity to enhance inhibitory neurotransmission, antagonises AMPA kainate glutamate receptors to reduce excitatory drive, and inhibits carbonic anhydrase enzymes.